Three-time Premier League 2 champions Manchester United are battling to maintain their Division 1 status, and they are one of seven teams who could yet be relegated in what promises to be a close contest to beat the drop.
We look at Man Utd, Sunderland and the five other clubs yet to secure their safety.
To play: DER (A), TOT (H), LIV (A)
A run of three successive victories was halted by a defeat at second-placed Arsenal, but the Blues should only need two more points to secure their status.
To play: MCI (A), EVE (A), DER (A), ARS (H)
West Ham, promoted from Division 2 last season, have won once in their last five outings but can all-but guarantee safety with one more victory.
To play: EVE (A), WHU (H), MUN (H), TOT (A)
Consecutive victories have eased Manchester City's concerns, and two wins from their last four matches would be enough to secure safety.
To play: CHE (H), TOT (A), WHU (H), LEI (A)
Derby, who finished with back-to-back wins to avoid relegation last season, have only won one of their last five matches and most recently suffered a 4-0 home defeat to relegation rivals Man City.
To play: DER (H), CHE (A), MCI (H)
Spurs have moved out of the bottom two thanks to a five-match unbeaten run, with a north London derby victory over Arsenal one of three wins in that sequence.
To play: MUN (A), LEI (H), SWA (A)
The Black Cats have lost three of their last five matches, but they won their last outing against Everton.
After their trip to Old Trafford, Sunderland will hope for more success against those vying for the title, as they face two of the top three teams.
To play: SUN (H), MCI (A), EVE (H)
Man Utd won 2-1 at title-chasing Liverpool on 9 March. But if Derby County avoid defeat against Chelsea on 31 March, it will mean United must not lose at home to Sunderland six days later to have a chance of staying up.