And one player on Pep Guardiola’s side will be particularly relishing the return to north London as he seeks to achieve a feat he has never managed before.
Sergio Aguero has scored in each of his last five appearances against Arsenal in all competitions.
The run started towards the end of 2015/16 with a goal in the 2-2 draw at the Etihad Stadium.
Since then, he netted against the Gunners in the FA Cup and Premier League last season before converting a penalty in the league and opening the scoring at Wembley Stadium on Sunday.
Never before has the Argentinian scored in six matches in a row against one team.
But he could set the record against an Arsenal defence which have not kept a clean sheet in their last nine Premier League matches. They last went 10 without a shutout in the league in February 2002, in a run of 11 matches.
|08/05/16||PL||MCI 2-2 ARS||1|
|02/04/17||PL||ARS 2-2 MCI||1|
|23/04/17||FA Cup||ARS 2-1 MCI||1|
|05/11/17||PL||MCI 3-0 ARS||1|
|25/02/18||EFL Cup||ARS 0-3 MCI||1|