Southampton's Shane Long (hamstring) and Steven Davis (knock) are both doubts, while Maya Yoshida (knee) and Charlie Austin (hamstring) remain sidelined.
Stoke City duo Peter Crouch and Ryan Shawcross are back in contention after overcoming ankle injuries, but goalkeeper Lee Grant is set to miss the coming weeks after breaking his wrist.
Southampton have both scored and conceded in 17 of their 28 PL matches this season, already once more than in the entirety of 2016/17 (16/38).
Manolo Gabbiadini’s strike against Burnley last Saturday was his first in 15 PL matches for Southampton. He last scored in consecutive matches in March 2017, registering in his first three top-flight appearances for the club.
Stoke City have won their last two league visits to St Mary’s Stadium, both by a 1-0 scoreline.
Peter Crouch has scored 12 goals in 53 PL matches against sides he once played for in the competition, with four of those (33%) coming against Southampton for Stoke.
Referee: Anthony Taylor
Assistants: Gary Beswick, Adam Nunn
Fourth official: Andre Marriner