Tottenham Hotspur have a full contingent to choose from but will assess the match-readiness of midfielder Lucas Moura.
Arsenal have doubts over goalkeeper Petr Cech (calf), but Danny Welbeck (muscular) and Nacho Monreal (illness) are expected to return.
Harry Kane has scored six goals in six Premier League matches against Arsenal, only failing to score in one those matches, the reverse fixture this season.
Tottenham Hotspur have lost only one of their last seven Premier League matches against Arsenal (W2 D4), although that defeat came this season, 2-0 at Emirates Stadium.
Arsenal have won more Premier League London derbies away from home (52) and in total (121) than any other side in the competition.
The Gunners are aiming to win home and away in the PL against Spurs in the same season for the fourth time, doing so in 2004/05, 2007/08 and 2013/14.
Referee: Anthony Taylor
Assistants: Gary Beswick, Adam Nunn
Fourth official: Neil Swarbrick