Manchester City manager Pep Guardiola says he is unsure how long Fabian Delph will be unavailable for with a knee injury.
Captain Vincent Kompany (calf) has a chance of returning, though may not be rushed back. Gabriel Jesus, Benjamin Mendy (both knee) and Phil Foden (ankle) are long-term absentees.
Newcastle United have reported no new injuries but Florian Lejeune (ankle), Aleksandar Mitrovic (back) and Chancel Mbemba (knee) remain doubtful.
Manchester City are unbeaten in 20 Premier League matches against Newcastle United (W17 D3), their longest unbeaten run against a side in their league history.
Teams managed by Rafa Benitez have kept four clean sheets at the Etihad Stadium in the Premier League. Only Sir Alex Ferguson, with five, has recorded more as an away manager.
Newcastle United can win three back-to-back PL away matches for the first time since December 2001.
Sergio Aguero has been directly involved in 13 PL goals against Newcastle (11 goals, 2 assists), averaging a goal or assist every 49 minutes.
Pep Guardiola: "We knew about the problem with Delph but in this kind of situation, we will see the reaction of the players, as it may not be their natural position [they are required to play in]."
Rafa Benitez: "They are so good, there is never a good time to play them. They are top of the table and winning almost every game, until the last one. So we don’t have any pressure."
Referee: Paul Tierney
Assistants: Simon Bennett, Marc Perry
Fourth official: Craig Pawson