It hands both FPL managers and his head coach Pep Guardiola a selection headache.
Sane has been sold more than any other player (266,000+ sales) ahead of Saturday’s 11:30 GMT deadline, leading to a drop of £0.1m in price.
With a derby against Manchester United next weekend, Guardiola must decide whether to risk starting the trio against the Hammers.
Both started on the bench in midweek, with Salah requiring only 23 minutes to produce two goals and 13 points at Stoke City.
He is the most popular player in FPL with 51.5% ownership, although Coutinho is found in just 5% of squads.
His average of 6.4 points per match is ranked fourth among midfielders.
The Brazilian could prove an effective differential over a run of six matches in the next seven that score two in the Fixture Difficulty Rankings (FDR).
That rest will prepare the Belgian for the visit of Newcastle United as he bids to maintain the form that produced three goals and two assists over the last five Gameweeks.
With the Frenchman ruled out through injury, manager Arsene Wenger could shift Alexis Sanchez (£11.8m) into the lone striker role.
The Chilean was last season’s top-scoring FPL player and has struck in each of the last three Gameweeks.
Those injuries to key defenders and a recent run of two clean sheets in the last six Gameweeks has had an impact on the FPL market.
David De Gea (£5.8m), the top-scoring goalkeeper, is also the most sold (30,000+ sales) ahead of Gameweek 15.