Swansea City winger Wayne Routledge (muscular) is doubtful but defender Federico Fernandez is in contention for a start after a leave of absence for personal reasons.
Long-term absentee Kyle Bartley (knee) is back in training but will play for the PL2 team before being considered.
Manchester City captain Vincent Kompany (muscular) has been ruled out but the leaders have no other concerns.
Manchester City are aiming for their 15th top-flight win in a row, which would beat Arsenal’s 14-match record run in 2002.
Man City have won 75% of their Premier League matches against Swansea (9 of 12), their best win rate against an opponent whom they’ve faced more than five times.
Swansea City's Wilfried Bony, formerly of Man City, has scored in his last two PL matches and is aiming to score in three in a row for the first time since October 2014.
The only players with more PL assists within a calendar year than Kevin De Bruyne's current total of 17 are Mesut Ozil (20 in 2015) and Thierry Henry (19 in 2003).
Paul Clement: “We are the underdogs, there’s no question about that. We know it will be tough but we will try to make it as hard for them as we can.”
Pep Guardiola: “In the future we can drop points, the league will be open again. People will think we have already won the Premier League, I don’t think that."
See: Guardiola on Kompany
Referee: Anthony Taylor
Assistants: Lee Betts, Peter Kirkup
Fourth official: Lee Probert