Michael Carrick, Paul Pogba (thigh), Marcos Rojo and Zlatan Ibrahimovic (both knee) have all been ruled out for Manchester United.
Antonio Valencia (knock) will be assessed and Marouane Fellaini (foot), Phil Jones and Anthony Martial (thigh) are doubtful.
Crystal Palace are without Christian Benteke (knee), Ruben Loftus-Cheek (thigh), James Tomkins (illness), Wilfried Zaha and Connor Wickham (both knee).
Loanee Timothy Fosu-Mensah is unavailable due to being ineligible to face his parent club.
Did you know?
Manchester United have never lost a Premier League match against Crystal Palace in 16 previous meetings (W13 D3). The only team they’ve faced as often without losing are Charlton Athletic (W14 D2).
Man Utd have won 10 consecutive home top-flight matches against Crystal Palace, conceding only two goals in that time and both of those came in the same match.
Romelu Lukaku (six in six) is aiming to equal or surpass Andrew Cole's record tally of goals by a Man Utd player in their opening seven PL matches for the club (seven)
Juan Mata is one away from becoming the seventh Spanish player to reach 200 PL appearances, after David De Gea, David Silva, Cesc Fabregas, Pepe Reina, Mikel Arteta and Fernando Torres.
What the managers say
Jose Mourinho: "[Roy is an] experienced manager, [he has] good players. [there is] a long time to fight to reach their objectives.”
Roy Hodgson: "We will go to Old Trafford with a belief that we can get a result and I know this group will have the confidence."
See: Who Hodgson might play as striker
Referee: Mike Dean
Assistants: Simon Long, Matthew Wilkes
Fourth official: Stuart Attwell
