Pogba will be out for several weeks with a hamstring problem suffered in the UEFA Champions League on Tuesday.
The Manchester United player is the top-scoring midfielder, having returned 31 points in the first four Gameweeks and is owned by 30.3% of managers.
His injury has already resulted in 433,000+ sales ahead of Friday night's 19:00 BST deadline.
The Belgian came off the bench to score in a 3-0 win over Basel on Tuesday night.
Jurgen Klopp could turn to Philippe Coutinho (£8.8m) in Mane's absence.
The Brazilian was given a first appearance of the season as a substitute in the UEFA Champions League draw with Sevilla on Wednesday.
Coutinho or Alex Oxlade-Chamberlain (£6.0m) can occupy the left-wing role in Liverpool's 4-3-3 formation.
Burnley arrive at Anfield after confirming Tom Heaton (£5.0m) is set for an extended period out after surgery on a dislocated shoulder.
Heaton was last season's top-scoring goalkeeper and his absence will likely allow Nick Pope (£4.5m) to stake a claim for regular starts.
Burnley’s upcoming schedule is somewhat mixed, though. Each of their next three away matches score four in the Fixture Difficulty Rankings (FDR).
Another of last season’s favourites will be assessed after stepping up his recovery from injury.
The Egyptian is the most-transferred in player in FPL, with more than one million new owners since the start of the season, but was replaced on 56 minutes with his side 2-0 down at Brighton & Hove Albion in Gameweek 4, returning zero points.
Pep Guardiola's side won the corresponding fixture 5-0 last season and have scored nine goals in their last two matches in all competitions.
The FPL GW5 deadline is Friday 15 September, 19:00 BST