The 48%-owned striker has also scored in nine of his last 10 appearances against the Hammers in all competitions.
Kane’s average of 7.5 points per match (ppm) in 2016/17 was more than any player.
He faces a side who kept only eight clean sheets in 23 home fixtures in the Championship last term.
Owned by 26.8%, the in-form De Bruyne has delivered four assists over the summer.
Jesus’s average of 6.7 ppm was second only to Kane among FPL forwards in 2016/17. Aguero produced a two-goal haul away from home on five occasions last term, with 15 of his 20 goals arriving on the road.
Felllow midfielder Sadio Mane (£9.5m) will also threaten the Hornets' defence. His average of 5.8ppm was more than any Reds team-mate last season.
Arsenal will likely turn to summer signing Alexandre Lacazette (£10.5m) against visitors Leicester City in Friday’s night’s season opener.
The Frenchman scored 28 goals for Lyon last season and his 33.3% goal conversion rate higher than any FPL forward.
Backed by a 17.2% ownership, Lacazette will be the main Arsenal option for managers with Alexis Sanchez (£12.0m) ruled out through injury.
The pair have scored five and four times respectively over the summer ahead of a Stamford Bridge meeting with Burnley.
Reminder - GW1 deadline is Friday 11 August, 18:45 BST