It’s a truncated Matchweek 29 this weekend, but the matches will still have a crucial impact at both ends of the table.
There's a HUGE relegation battle at Kenilworth Road on Saturday when Luton Town host Nottingham Forest.
The Hatters looked to have clawed their way out of the bottom three on Wednesday night when they went 3-0 up at AFC Bournemouth, but then in an incredible match, the Cherries hit four second-half goals to seal a 4-3 win and leave Luton in the relegation zone, just three points behind 17th-placed Nott'm Forest.
A win at home, something they have only managed twice in their last eight at Kenilworth Rd, could be pivotal for Luton’s ability to claw their way to safety.
Following a run of three straight Premier League defeats, Forest are perilously close to the relegation zone, although all three losses did come against teams in the top half of the table.
If Nuno Espirito Santo’s side wants to remain in the top flight for a third consecutive season, a road win at Luton would go a long way towards that goal.
A thundering 4-0 victory at Aston Villa last weekend has blown the door to the top four wide open for Tottenham Hotspur and now their next challenge will be a London derby against Fulham. Spurs now sit only two points behind Villa.
Their supporters have to feel optimistic about closing that gap further. But they can’t afford a letdown match against 12th-place Fulham, who recorded impressive wins over Manchester United and Brighton & Hove Albion before losing 2-1 at Wolverhampton Wanderers last time out.
Only the top five clubs and Newcastle United have won more home games this season than Fulham, proving they will not be an easy out at Craven Cottage.
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Sunday’s lone match is a top-seven clash between West Ham United and Aston Villa at London Stadium.
Both sides are coming off disappointing results, with Spurs thrashing Villa 4-0 and West Ham only managing a 2-2 home draw against struggling Burnley.
With Spurs hot on their heels, Unai Emery’s side would love to reverse their fortunes and pick up a huge three points on the road.
The key for the Hammers will be to contain Villa’s attack in the first half, as only Arsenal, with 31 goals, have scored more than Villa's 29 goals in the opening 45 minutes.
West Ham are four points off Man Utd, who are in sixth spot, but there's a group of four teams behind them within striking distance. After winning two of their last three, David Moyes will want to keep the momentum going with a big West Ham win.
Tune in for this one. Watch the match on USA and Telemundo on Sunday at 10:00 AM ET. Stream here: