It has been a difficult start for the Blades so far, with their only point coming against Everton in Matchweek 4.
Sheff Utd were heading for an unlikely victory against Tottenham Hotspur last weekend, but goals from Richarlison and Dejan Kulusevski in the eighth and 10th minute of second-half stoppage time gave Spurs the three points in the the latest comeback in Premier League history.
Newcastle have endured their own misfortunes in the opening weeks of the season, having only faced teams who finished in the top nine last campaign with wins against Aston Villa on the opening weekend and Brentford last time out sandwiching three consecutive losses to Manchester City, Liverpool and Brighton & Hove Albion.
As for the hosts, Rhian Brewster, John Fleck, Ben Osbourne, Max Lowe, Rhys Norrington-Davies, George Baldock and Daniel Jebbison all remain sidelined, while Oliver McBurnie will serve a one-match suspension.
However, there is one piece of positive team news, with experienced defender John Egan back in training and available for the weekend, as Paul Heckingbottom revealed in his pre-match press conference.
Last five meetings
Newcastle 1-0 Sheff Utd - 19 May 2021
Sheff Utd 1-0 Newcastle - 12 January 2021
Newcastle 3-0 Sheff Utd - 21 June 2020
Sheff Utd 0-2 Newcastle - 5 December 2019
Newcastle 2-1 Sheff Utd - 5 April 2010 - Championship
None of the eight Premier League meetings between Sheff Utd and Newcastle have been drawn, with the Blades winning three of these. Two of their three victories have come in home matches, in April 1994 and January 2021.
Newcastle have lost both of their Premier League away contests so far this season, only one fewer defeat than they suffered on the road in the whole of last season.
Sheff Utd have had fewer shots per match than any other Premier League side this season with an average of 8.2, while their 114 shots faced is the highest in the division.
What the managers had to say
Eddie Howe: "(We’re expecting) a difficult game. I think Bramall Lane is a very tough place to go, anytime of the year. They’re a good team, a direct team who will ask us questions physically. They’ve got good athleticism in their team, counter-attacking, and they’re very strong from set plays." More details
Paul Heckingbottom: "The challenge of the Champions League is different to us but we'll set up to create chances and cause problems." More details