Here's what to look out for over the next seven days involving Premier League clubs.
Newcastle will play their first Champions League match for 20 years, facing AC Milan at San Siro at 17:45 BST, while Man City host Red Star Belgrade at 20:00 BST.
Arsenal will play their first Champions League match since 2016/17 as they entertain PSV Eindhoven at Emirates Stadium from 20:00 BST.
Brighton & Hove Albion's dream European debut will start with a home match against AEK Athens in the UEFA Europa League at The Amex Stadium at 20:00 BST.
Aston Villa continue their continental adventure after thrashing Hibernian in the UEFA Europa Conference League playoff round, with Emery's side taking on Legia Warsaw in Poland at 17:45 BST.
West Ham United look to take their strong Premier League start into Europe and enjoy another long run after winning last season's Europa Conference League, welcoming Serbia's Backa Topola to the London Stadium at 20:00 BST.
Liverpool, participating in the UEFA Europa League for the first time since 2016, travel to Austrian side LASK, starting at 17:45 BST.
In the Premier League, some clubs' managers will be holding their press conferences ahead of the weekend's fixtures.
The remaining Premier League managers will face the media, providing the latest injury and fitness news.
Matchweek 6 of the Premier League starts at a slightly later time of 15:00 BST (giving Fantasy Premier League managers some extra hours to sort out their teams, with a deadline of 13:30 BST), but also a later finish.
The 10 fixtures are split evenly across the two days, with five on Saturday, as Man City look to extend their winning start to six matches as they welcome Forest.
Burnley welcome Man Utd in a 20:00 BST start to finish the day.
The standout fixture of the weekend takes place on Sunday 14:00, with the first north London derby of the season.
The dream start for Ange Postecoglou and Tottenham Hotspur will be severely tested by the Gunners. Both teams have yet to taste defeat in 2023/24, making this meeting the first in the Premier League era where the two teams remain unbeaten.