Sergio Aguero will be aiming to continue the second-best goal ratio against London teams in the Premier League era when Manchester City visit Arsenal on Sunday.
Elsewhere, Jurgen Klopp eyes a record-breaking Merseyside derby treble, while Craig Shakespeare could join an exclusive club of PL managers should Leicester City beat Stoke City.
(All kick-offs are 3pm BST unless stated otherwise)
Saturday 1 April
Liverpool v Everton, 12.30pm
Burnley v Spurs
Chelsea v Crystal Palace
Hull City v West Ham
Leicester v Stoke City
Man Utd v West Brom
Watford v Sunderland
Southampton v AFC Bournemouth, 5.30pm
Sunday 2 April
Swansea v Middlesbrough, 1.30pm
Arsenal v Man City, 4pm