A packed festive period of three Matchweeks in just over a week will start on the weekend of Saturday 23 December, with Liverpool v Arsenal the standout tie, followed by Crystal Palace hosting one of their fiercest rivals Brighton & Hove Albion.
On Boxing Day, there will be two London derbies as Arsenal host West Ham United for the second year running, while Chelsea are at home to Palace.
Brighton will face Tottenham Hotspur at home while Manchester United v Aston Villa could be a key match for both clubs' European hopes.
See: All 380 Premier League fixtures
Two of the promoted clubs, Sheffield United and Luton Town, will meet in Yorkshire, while the other team to have come up from the Championship, Burnley, will host Liverpool, against whom they claimed a famous victory in .
The Gunners will aim to continue their strong run of home form against West Ham, whom they have beaten in their last seven fixtures at Emirates Stadium, including a 3-1 success on Boxing Day last year.
Chelsea edged to a narrow 1-0 win when they last hosted Palace in January, while Man Utd won by the same scoreline in their April meeting with Villa.
Minimum gap of 48 hours
The final fixtures of the festive period will take place on Saturday 30 December, and will feature another pair of London derbies with Palace hosting Brentford, while Arsenal travel to Craven Cottage to face Fulham.
Liverpool v Newcastle United looks set to be the standout encounter of that Matchweek.
In keeping with commitments made to clubs to address the congested schedule across Christmas and New Year, no two rounds over the festive period period will take place within 48 hours of each other.