Liverpool manager Jurgen Klopp confirmed Firmino, who has been transferred in by more than 103,000 managers since last weekend, picked up a knock during last Saturday’s 3-1 win over Arsenal and failed to train earlier in the week.
Burnley are boosted by the return of Tom Heaton (£5.1m) for the trip to Anfield after the goalkeeper and captain recovered from the illness that forced him out of the Gameweek 27 defeat at Swansea City.
The versatile attacker could partner Andy Carroll (£6.2m) in a 4-4-2 formation at Vitality Stadium or could play on the right of a 4-2-3-1, with Sofiane Feghouli (£5.0m) making way.
AFC Bournemouth have worries in defence, with Tyrone Mings (£4.5m) starting his five-match suspension and Simon Francis (£4.6m) in a race to be fit after a hamstring problem.
Steve Cook (£4.8m) could be partnered by 21-year-old Baily Cargill (£4.0m) in the heart of the Cherries’ back four, with manager Eddie Howe seeking to address a run of form where his side have conceded at least two goals in all but one of the last eight Gameweeks.