Subject to more sales than any FPL defender prior to tonight's 6.45pm GMT deadline, Van Dijk’s absence will likely see Maya Yoshida (£4.2m) partnered by another budget option, Jack Stephens (£4.0m), in the heart of Claude Puel's backline.
Tottenham Hotspur received a boost in attack and defence ahead of a trip to Sunderland after Harry Kane (£11.2m), Toby Alderweireld (£6.3m) and Danny Rose (£6.1m) recovered from knocks that ruled them out of the weekend FA Cup win over Wycombe Wanderers.
More than 73,000 Fantasy Premier league managers have drafted in Kane for Gameweek 23, having netted six times in the last five rounds of fixtures.
With two of their first-choice defenders back in contention, Spurs will be looking to claim a 10th clean sheet of the season against a Black Cats attack with a single goal in their last four matches across all competitions.
After missing the Reds' weekend FA Cup loss to Wolverhampton Wanderers, Lallana has been subject to more than 180,000 trades out - more than any other player in the Gameweek.
Mane's potential return to the right of Liverpool's front three could mean that Lallana switches back into central midfield against the league leaders.
Jose Mourinho has also confirmed that Antonio Valencia (£5.5m), Paul Pogba (£8.5m) and Zlatan Ibrahimovic (£11.7m) - who all played no part in Sunday’s FA Cup win over Wigan Athletic - will return to his starting line-up.
The Argentinian, who missed the weekend FA Cup win at Crystal Palace, has been transferred out by more than 48,000 FPL managers after netting only once in his last five Gameweek appearances.
City's January signing Gabriel Jesus (£9.0m) is also expected to be available. The Brazilian earned an assist on his first start for the Etihad side in the triumph at Selhurst Park.
Expected to recover from a muscle problem that meant he sat out Gameweek 22, the 9.9%-owned Snodgrass produced a goal or assist in each of his final three appearances for former club Hull City.
Indeed, despite missing the trip to Chelsea last time out, no player has created more chances than Snodgrass over the last four Gameweeks.