Top-scorer Aguero suffered a knock in the Matchweek 22 draw with Tottenham Hotspur but the striker is fit and in contention along with Fernandinho, who has served out a four-match suspension.
“Yes, he (Aguero) trained with the team so he is ready,” Guardiola told mancity.com.
“Fernandinho is so important. We play a lot of games without him. I am happy he is back. Of course, it is important for us.”