Widespread media reports suggest Hugo Lloris is set to be ruled out for between six to eight weeks.
The Tottenham Hotspur goalkeeper is believed to have suffered a knee injury during Sunday's 1-0 win over Manchester City.
Such a timeframe of absence would result in the France international missing up to six Premier League matches and represent a huge blow to the club's top-four hopes.
Antonio Conte's side lie fifth in the table, a point behind Newcastle United having played a match more.
| Position Pos | Club | Played Pl | GD | Points Pts |
|---|---|---|---|---|
| 3 |
Man Utd
MUN
|
38 | +15 | 75 |
| 4 |
Newcastle
NEW
|
38 | +35 | 71 |
| 5 |
Liverpool
LIV
|
38 | +28 | 67 |
| 6 |
Brighton
BHA
|
38 | +19 | 62 |
| 7 |
Aston Villa
AVL
|
38 | +5 | 61 |
Lloris, 36, would also miss both legs of hisside's last-16 UEFA Champions League tie against AC Milan, with the first leg set to take place on 14 February.
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Lloris's likely deputy, Fraser Forster, has started one Premier League match since joining Spurs last summer from Southampton, a 2-2 draw at Brentford in December.
Spurs are already without defender Cristian Romero for Saturday's trip to Leicester City following his sending-off for two bookable offences in the victory over Man City.