After a weekend off for FA Cup fixtures, the Premier League is back with a full slate of action for Matchweek 22.
The first test for newly-appointed Everton manager Sean Dyche is a tough one as the Toffees host table-topping Arsenal at Goodison Park on Saturday.
Everton's poor run of form has seen them drop to 19th place but still only two points off away escaping the relegation zone.
Taking one point against the Gunners would be a major accomplishment for Dyche against the in-form Gunners. Two straight statement wins in the Premier League against Tottenham Hotspur and Manchester United have strengthened their position at the top, but now Mikel Arteta’s side need to avoid a letdown against Everton.
There's another top-versus-bottom fixture in store this weekend when Newcastle United host West Ham United at St James' Park.
Eddie Howe's side have exploded into the top four this season and will look to Saturday's match as a prime opportunity to add three more points and maintain Newcastle's hold on third place.
West Ham picked up a massive win over Everton last time out that moved them out of the relegation zone but the Hammers are not safe by any means. Stealing points on the road against a top side could be a key step in their battle to stay up.
Spurs will have revenge in mind when they host Manchester City in a mouthwatering top-five match-up on Sunday.
The two teams met barely two weeks ago at the Etihad Stadium when Spurs roared into a 2-0 lead at the halfway stage and looked to pull off a major victory.
But Man City responded with a flurry of goals in the second half to win 4-2 and take the three points.
Now Antonio Conte's side, who are three points outside of the top four, will be looking for a result to set the tone for the rest of their season.
Man City on the other hand, sit firmly in second place, five points behind leaders Arsenal who are at Everton. Pep Guardiola's Cityzens won't want to drop further points and possibly the weekend even further behind their title rivals.
This one is going to be good. Watch the match on NBC at 11:30 AM ET.