The Newcastle United right-back has blanked just twice in his eight appearances, combining a goal and an assist with four clean sheets.
His visitors, meanwhile, arrive at St James’ Park having failed to score in their last two matches.
Trippier and team-mate Callum Wilson (£7.2m) are selected in a best XI that lines up in a 3-5-2 formation, with Erling Haaland (£12.2m) handed the armband and Jarrod Bowen (£8.1m) named as vice-captain.
The Manchester City full-back has two double-figure hauls in his four home matches ahead of a visit from Southampton. Cancelo is the most-popular defender in Fantasy, selected by 51.7 per cent owners.
He is the most-bought defender in the Gameweek, earning 348,000 new owners.
The Chelsea midfielder has 22 points in his three home appearances, scoring twice and supplying an assist. Sterling’s 14 shots and 11 chances created are both team-leading totals this term.
Man City’s winger has four goals and two assists in his previous five matches, including a hat-trick in a 6-3 home win over Manchester United last weekend. Foden will be fully refreshed to face Southampton, after being rested from UEFA Champions League duties in midweek.
The West Ham United midfielder entertains Fulham on the back of a goal and an assist in a 2-0 win against Wolverhampton Wanderers. Bowen has produced 11 shots in the box from Gameweek 5 onwards, more than any other midfielder in Fantasy.
The Man City forward has scored a hat-trick in three successive home matches and averages 15.5 points per appearance at the Etihad Stadium this term. Haaland will be the go-to captain for millions of FPL managers against Southampton, who are the only side yet to keep a clean sheet in 2022/23.
Newcastle’s forward has scored in three of his four fixtures this season, including both his home appearances. Wilson hosts a Brentford side who have only one clean sheet in their last 20 away matches.
GW10 deadline: 13:30 BST, Sat 8 Oct