Manchester City's playmaker looks set to pose a major challenge to Erling Haaland (£11.7m), Mohamed Salah (£13.0m) and Gabriel Jesus (£8.2m), the top three captain picks in each of the last two Gameweeks.
De Bruyne produced 14 points in the champions' last home match, a 4-0 home win over AFC Bournemouth in Gameweek 2.
That continued his form from the previous campaign, where he averaged 8.7 points per start at the Etihad Stadium.
City team-mate Haaland has matched the Belgian's early-season output, with returns in each of the first three Gameweeks.
The Norwegian forward has been supplied with seven big chances, a league-leading total.
Salah entertains AFC Bournemouth on the back of three goals in his first three outings.
The Egyptian has a formidable record against promoted opponents, producing double-figure hauls in four of his last six matches.
Jesus, meanwhile, is in outstanding form for Arsenal's match with Fulham.
The Brazilian delivered 19 points in his first outing at Emirates Stadium and his huge 81 per cent ownership means he will be a popular captain pick.
Elsewhere, both Harry Kane (£11.4m) and Ivan Toney (£7.2m) provide further options for the armband.
Kane has scored in each of his last two outings ahead of Tottenham Hotspur's trip to Nottingham Forest.
Forest have conceded 61 shots and 21 shots on target, both more than any other side.
Brentford's Toney sits joint-top among forwards in Fantasy, with returns in each of the first three Gameweeks.
He is the most-bought player in his position for the Gameweek, earning 407,000+ new owners for the Bees’ home encounter with Everton.
Don't forget the Gameweek 4 deadline is 11:00 BST on Saturday 27 August.