After finding out which opponents lie in wait on the opening weekend, fans quickly turn their attentions to their club's big derby matches.
Among the biggest Premier League rivalries are those in north London, Merseyside and Manchester, while the south-coast derby is also back for 2022/23.
|3 Sep||Everton v Liverpool|
|1 Oct||Arsenal v Spurs|
|1 Oct||Man City v Man Utd|
|14 Jan||Man Utd v Man City|
|14 Jan||Spurs v Arsenal|
|11 Feb||Liverpool v Everton|
The first match-up comes on 3 September when Everton host Liverpool.
Frank Lampard suffered a 2-0 defeat in his maiden Merseyside derby as Everton manager at Anfield in April, but he will hope to deliver the Toffees' first win at Goodison Park over the Reds since a 2-0 victory in 2010.
On the weekend of 1 October, Arsenal entertain north-London rivals Tottenham Hotspur while Erik ten Hag's first Manchester derby will be at the Etihad Stadium.
History suggests the Gunners could have the edge over Spurs, given there have been no away wins in the last 16 Premier League meetings between the clubs.
But ten Hag can take confidence from the fact that United have won on four of their last seven visits to the Etihad Stadium.
On the same weekend, Man City head to Old Trafford. Like in the reverse fixture, it's the away side that tends to fare better in his match-up, with City emerging victorious on four of their last six trips.
Interestingly, the home side have won only one of the last nine meetings in all competitions.