Bamford will miss the meeting with West Ham United and their star striker Antonio this weekend due to an ankle injury, with head coach Marcelo Bielsa unsure when he will return.
As a result, Bamford has been sold by 210,000+ managers in the last 24 hours, more than any other player.
After serving a one-match suspension in Gameweek 5, Antonio has emerged as the favourite replacement.
Most-popular Bamford replacements
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More than 176,000 Bamford owners have brought in the Hammers striker since the last deadline passed.
Antonio has produced three double-figure hauls in his four outings this term.
And his 18 shots and 15 shots in the box both rank top among forwards in Fantasy.
Allan Saint-Maximin (£6.7m) and Cristiano Ronaldo (£12.7m) have also have also been popular signings for those selling Bamford.
Saint-Maximin has blanked in just one of his five matches for Newcastle United in 2021/22.
Meanwhile, Ronaldo's 13 shots and 12 shots in the box in the last two Gameweeks since returning to Manchester United are both league-leading totals.
Joshua King (£5.5m), Teemu Pukki (£5.9m) and Adam Armstrong (£6.0m) can also appeal as value picks.
Armstrong has recorded 16 shots, at least double the total of any other Southampton player, and has a very favourable schedule.
According to the Fixture Difficulty Ratings (FDR), five of Saints' next seven matches score only two.
Remember, the Gameweek 6 deadline is at 11:00 BST on Saturday 25 September.