A home encounter with Leicester City gives Michail Antonio (£7.6m) the chance to retain his place as the top-scoring forward in Fantasy Premier League.
The West Ham United striker produced 13 points last weekend, scoring once and supplying two assists in a 4-2 win at Newcastle United.
He will look to take advantage of a Leicester side who conceded 12 shots in the box in Gameweek 1, a total fewer than only two other sides.
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Encouragingly for the Hammers, they won both their meetings against Brendan Rodgers’ men last term, scoring three goals on each occasion.
That also earns Said Benrahma (£6.1m) a place in a 3-5-2 formation, with Mohamed Salah (£12.6m) handed the armband and Bruno Fernandes (£12.1m) named vice-captain.
Vicente Guaita (CRY) £4.5m
The Crystal Palace No 1 welcomes Brentford on the back of a strong home record against promoted sides last season. Guaita produced 20 points in those three matches, conceding only one goal.
Trent Alexander-Arnold (LIV) £7.5m
A home meeting with Burnley lifts the Liverpool right-back’s prospects of starting the season with successive clean sheets. Alexander-Arnold’s role as the Reds’ main set-piece taker can also pose big problems for the Clarets.
Luke Shaw (MUN) £5.5m
Manchester United’s left-back is the third most-selected player in Fantasy, owned by over 54 per cent. Shaw can reward their faith with points at both ends of the pitch at Southampton.
Shane Duffy (BHA) £4.0m
The Brighton & Hove Albion centre-back offers strong value at home to Watford. Duffy's four shots in the box in Gameweek 1 were more than any other defender in Fantasy.
Mohamed Salah (LIV) £12.6m
Liverpool's Egyptian opened the campaign with a 17-point haul against Norwich City. Salah was captained by a record-breaking 2.6million managers in Gameweek 1 and will again be a big favourite for the Reds' first home match of 2021/22.
Bruno Fernandes (MUN) £12.1m
His hat-trick against Leeds United earned the Portuguese 20 points, his best-ever haul in Fantasy. Fernandes thrived in his last meeting with Southampton, producing a goal and two assists in a 9-0 victory.
Riyad Mahrez (MCI) £9.0m
An ownership of only 7.7 per cent makes the Manchester City winger a major differential for the captaincy against Norwich. Four of Mahrez’s five double-figure hauls last season came in home matches.
Raphinha (LEE) £6.5m
Leeds' Brazilian was a big success in his meetings with this weekend's visitors Everton last term. Raphinha scored and earned nine points in both his appearances against the Toffees.
Said Benrahma (WHU) £6.1m
His goal and assist at Newcastle have made the Algerian a top target for managers in Gameweek 2. Benrahma has earned 218,000+ transfers in for his home match against Leicester, making him the third most-bought midfielder in Fantasy.
Michail Antonio (WHU) £7.6m
An ownership of 27.7 per cent makes him the third most-owned forward in Fantasy.
Dominic Calvert-Lewin (EVE) £8.1m
The forward was on the scoresheet in Everton's 3-1 comeback win over Southampton in Gameweek 1. Calvert-Lewin was a huge influence on the road last term, involved in a team-leading 60 per cent of the Toffees' away goals when selected.
Tomorrow: Scout Selection: The FPL experts' views
See: The Scout's essential FPL tips for Gameweek 2
Remember, the Gameweek 2 deadline is at 11:00 BST on Saturday 21 August.