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Arsenal are targeting a third successive league win over Chelsea for the first time since February 2004.
The Gunners have not beaten Chelsea in any of the last 10 Premier League meetings on a Sunday (D2 L8), since winning 2-1 in November 2008 at Stamford Bridge.
Chelsea have won their last four Premier League away London derbies, last winning five in a row between January 2005 and January 2006 under Jose Mourinho.
Chelsea goalkeeper Edouard Mendy has kept more Premier League clean sheets (10) than any other goalkeeper since Thomas Tuchel took charge in January.
Referee: Paul Tierney. Assistants: Constantine Hatzidakis, Neil Davies. Fourth official: David Coote. VAR: Chris Kavanagh. Assistant VAR: Sian Massey-Ellis.