If Liverpool match Leicester City's result, they will finish in the top four.
Leicester can only leapfrog the Reds if they outperform Liverpool's result in their match with Tottenham Hotspur by four goals.
If Liverpool fare better than Chelsea, they could move above them into third.
A win for Palace will guarantee them a 12th-placed finish.
Team news
Did you know?
Sadio Mane can be the second player in PL history to score in eight consecutive matches against an opponent.
Liverpool won 7-0 at Selhurst Park in the reverse fixture. The most goals they’ve scored against an opponent in a single PL season is 11 (v Ipswich in 2001/02).
Roy Hodgson’s last match in charge of Crystal Palace will be his 364th in the Premier League, the eighth-most of any manager.
Christian Benteke’s four goals scored at Anfield are second only to Andrew Cole (eight) for the most by a visiting player.
Match officials
Referee: Craig Pawson. Assistants: Richard West, Scott Ledger. Fourth official: Tony Harrington. VAR: Paul Tierney. Assistant VAR: Eddie Smart.