Their meeting with Saints looks particularly appealing for Kane and Son.
The pair produced their season-high hauls of 21 and 24 points respectively in their previous meeting with Ralph Hasenhuttl’s men, a 5-2 win in Gameweek 2.
Southampton have also been in poor defensive form recently, conceding 12 goals in their last four matches.
Five attacking players have produced double-figure hauls against them in that period, while West Bromwich Albion’s Matheus Pereira (£5.4m) claimed nine points on Monday.
Of the Spurs duo, Kane has been the more reliable for returns. He has blanked in only 11 Gameweek appearances, while Son has done so on 16 occasions.
But Son has been more explosive this season, claiming nine double-figure hauls compared with the seven of Kane.
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Over their respective last four matches, Kane has the edge for goal threat.
Nonetheless, it is worth noting that Son bettered him by four shots in the penalty area to one against Manchester United last weekend, with Kane also failing to create a single chance in his last four matches.
Managers who are brave enough to look beyond the Spurs pair must pinpoint players with the form and fixtures to potentially outscore them.
Leicester City frontman Kelechi Iheanacho (£6.0m) is at home against West Brom, having produced seven goals and 50 points in his last five matches.
Arsenal’s Alexandre Lacazette (£8.3m) has five goals and 43 points over his last six matches and has a home fixture versus Fulham.
Premium big-hitters Bruno Fernandes (£11.6m) and Mohamed Salah (£12.5m) can never be ruled out either.
Fernandes’ 11 double-figure hauls in 2020/21 are more than any other player in Fantasy ahead of Man Utd's home match against Burnley.
Remember, the Gameweek 32 deadline is at 18:30 BST on Friday 16 April.