Adrian Clarke looks at key tactical points in Matchweek 23.
And from a tactical perspective, both right-backs will be of considerable importance to their respective managers.
They are two very different full-backs, but each has the ability to impact the outcome of this match.
When it comes to creating chances in open play this term, Cancelo's 30 are second only to the 38 of Kevin De Bruyne.
Cancelo is brave in possession, happy to take opponents on or make an incisive forward pass.
He has delivered 90 passes into the opposition box, the second-highest number, again only topped by De Bruyne, while no other defender has laid on more key passes.
Cancelo’s positional play is also important for City's shape.
At times he starts as an orthodox central midfielder, and this is a possibility at Anfield.
Cancelo did this against Arsenal in December and his pressing successfully disrupted them when they tried to play out from the back.
Without Cancelo’s versatility, City would be far easier to play against.
Alexander-Arnold’s form has fluctuated throughout the campaign, but he still poses a threat from the right.
With Liverpool's defence disrupted by injury, Alexander-Arnold has had to be more selective about when to press forward.
A return of just three assists, compared with his 13 last season, will be a source of frustration to Alexander-Arnold.
His crossing accuracy has marginally improved from 15.1 per cent to 15.2 per cent, but Liverpool are not profiting as much from this.
His 18 chances created from open play rank him eighth in the Premier League in this category, while he was second last term, averaging 1.33 per 90 minutes.
|Per 90||2019/20||PL rank||2020/21||PL rank|
|Passes into box||14.42||1st||12.19||1st|
Part of the problem has been a downturn in tempo and movement from Liverpool in possession.
When facing low blocks, Klopp’s side has been significantly more laborious than they were en route to becoming champions.
As a consequence, crosses from both full-backs have become easier to defend.
Both Cancelo and Alexander-Arnold are extremely important to their side and it will be fascinating to watch how both players perform in this crucial showdown.