Chris Wilder has revealed Sheffield United could be without seven players, with George Baldock, Enda Stevens, Jack Robinson and Oli McBurnie among those doubtful.
Sander Berge (hamstring) is still out.
Steven Bergwijn has returned to training for Tottenham Hotspur and could feature, but Giovani Lo Celso remains sidelined.
Sheff Utd have lost just two of their last 11 top-flight matches against Spurs (W5 D4) and picked up four points against them last season.
The Blades can be the first side to win consecutive Premier League matches when starting the day in bottom place since West Bromwich Albion in April and May 2018.
No side have scored more first-half PL goals this season than Spurs' 19, including a league-high eight goals in the opening 15 minutes. They have also shipped the fewest goals before half-time, with four.
Harry Kane and Son Heung-min's combined 43 shots on target is just nine fewer than Sheff Utd have managed as a whole so far in 2020/21.
Referee: Andre Marriner. Assistants: Richard West, Mark Scholes. Fourth official: Robert Jones. VAR: Mike Dean. Assistant VAR: Andy Halliday.