Burnley have doubts over the fitness of Charlie Taylor, Dwight McNeil and Jay Rodriguez, while they are waiting to learn the extent of Kevin Long's ankle injury.
Sean Dyche is hopeful of having Ashley Westwood, Josh Brownhill, Jimmy Dunne and Bailey Peacock-Farrell available.
Eric Bailly will be assessed after sustaining a sore neck in Manchester United's FA Cup win against Watford. Victor Lindelof, Luke Shaw and Paul Pogba all missed that match and will also be checked ahead of Tuesday.
Ole Gunnar Solskjaer has suggested that he will rotate his squad and has Edinson Cavani available after serving a three-match ban.
Burnley won 2-0 at Old Trafford in their last Premier League meeting with Man Utd, and can now win consecutive league matches against the Red Devils for the first time since September 1968.
Following victories against Wolverhampton Wanderers and Sheffield United, Burnley can record a third consecutive PL home win for the first time since January 2017.
Man Utd are averaging three goals per PL away fixture this season, after 21 in seven matches. Liverpool's average of 2.5 in 2013/14 is the highest across a full season.
Marcus Rashford has scored six goals in seven PL away matches this season. He has never netted more than six on the road in a single campaign.
Referee: Kevin Friend. Assistants: Simon Beck, Adrian Holmes. Fourth official: Peter Bankes. VAR: Stuart Attwell. Assistant VAR: Stephen Child.