Boxing Day is the first of five consecutive days of drama featuring 20 matches.
The standout match of the six traditional Premier League fixtures on Boxing Day will be the London derby between Arsenal and Chelsea.
The match round concludes on Sunday with Spurs travelling to Wolverhampton Wanderers, a meeting that has averaged four goals of late.
The final round of 2020 fixtures includes Everton hosting a resurgent Manchester City, Brighton & Hove Albion looking to stun Arsenal again at home and Newcastle United facing champions Liverpool, a fixture that has a history of goals.
After one day's rest, the action resumes on New Year's Day, starting with Everton v West Ham United, two teams looking to upset the top six.
The highlight of the remaining eight matches is the visit to Chelsea of Manchester City on Sunday 3 January.
The traditional New Year’s Day fixtures in England feature West Ham United travelling to Everton, followed by Man Utd taking on the in-form Aston Villa.
Chelsea v Man City headlines the next day of action, while the festive period wraps up with resurgent Southampton hosting the defending champions Liverpool.