Allan and Fabian Delph (both hamstring) and James Rodriguez (calf) have been ruled out for Everton, but Seamus Coleman is in line to make his first appearance since 7 November.
Lucas Digne (ankle) remains sidelined while Jean-Philippe Gbamin (Achilles) continues his rehabilitation.
Arsenal will be without Pierre-Emerick Aubameyang, who has a tight calf, and the suspended Gabriel and Granit Xhaka, following recent dismissals. Mikel Arteta has revealed there are several injury concerns for his side.
Everton have kept a clean sheet in each of their last two home Premier League fixtures against Arsenal (W1 D1), last keeping three in a row at home to them between November 1966 and April 1969.
Richarlison is looking to score in consecutive league appearances for the first time since February 2020, when the second match in this run came against Arsenal.
Arsenal have won more PL matches (34) and scored more PL goals (110) against Everton than they have versus any other opponent in the competition.
Pierre-Emerick Aubameyang has scored four goals in his four league starts against Everton, though all of these goals have come at home.
Referee: Andre Marriner. Assistants: Scott Ledger, Simon Long. Fourth official: Paul Tierney. VAR: Michael Oliver. Assistant VAR: James Mainwaring.