Although Ollie Watkins (£6.0m) hasn't kicked on since his haul against Liverpool there is a good chance that, alongside the likes of Ross Barkley (£6.0m) and Jack Grealish (£7.3m), he can get in behind the Southampton high line.
The performances of Sadio Mane (£12.0m) make him a great captain but I wouldn't overlook Harry Kane (£10.9m).
West Ham United have performed very well defensively in tricky looking fixtures, so rather than Liverpool I'll be looking at Kane and Son Heung-min (£9.5m) from Tottenham Hotspur for the captaincy. Son's currently got the nod as I think he'll find space in behind the forward-thinking Tariq Lamptey (£4.7m).
Really happy to see Ben Chilwell (£5.8m) and Phil Foden (£6.6m) in there, who are flying under the radar as top picks.
Mane as captain over Mohamed Salah (£12.4m) is justified given the big chances the former has accumulated of late.
Southampton will make it tough for Aston Villa so I wouldn't back the likes of Ezri Konsa (£4.7m) and Watkins. The rest of the picks look great, especially differential captain Mane.
I didn't expect double Villa. I like the midfield with Foden and think the only thing missing is a punt on a Chelsea attacker, although they may be difficult to afford.
Foden is an intriguing choice. Coming off the back of two man-of-the-match performances, he will be key to breaking down a Sheffield United side who are likely to sit deep.
Love the Chilwell pick. He is attacking a lot and on some set-pieces. He is in my team and with Thiago Silva (£5.5m) in defence and Edouard Mendy (£5.0m) in goal, Chelsea look great.
Mane captain is a big call and I'm sure it will divide people. For me, with penalty duties, you've got to go with Salah.
It's a midfield of dreams this week, with four heavy-hitters. I'll have to hope Bruno Fernandes (£10.5m) delivers as my midfield differential.
The three defenders have had great starts to the season but Villa will have their work cut out against a resurgent Southampton.
Don't get caught out. The Gameweek 7 deadline is at 18:30 GMT on Friday 30 October.