Dominic Calvert-Lewin will write his name into the Premier League record books if he continues his prolific start to the season and scores at Southampton.
For more on this and all the must-know stats for Matchweek 6, read on. To check out the head-to-head records, click on the fixtures.
If they avoid defeat, Aston Villa will finish a day top of the Premier League table for the first time since August 2011.
Wilfried Zaha has scored four goals in his five matches this season, as many as he netted in the whole of 2019/20.
Liverpool can extend their unbeaten Premier League run at Anfield to 62 matches. They have won 27 of their last 28 at home.
West Bromwich Albion have won just one of their 13 Premier League away matches played on a Monday (D5 L7), beating Liverpool 2-0 in 2013.
Tottenham Hotspur are aiming to win their first three away matches of a Premier League season for only the second time, after 2017/18.