Southampton are targeting a third win in four matches, having drawn their other contest 3-3 at Chelsea last time out.
Everton can move three points clear at the top of the table, having won four of their opening five matches and drawn the other against champions Liverpool.
Team news
Stuart Armstrong is back for Southampton after testing positive for COVID-19 while on international duty with Scotland.
Theo Walcott, however, is ineligible to face his parent club, and Moussa Djenepo (hamstring) is unavailable.
Everton will assess the fitness of James Rodriguez (knock). Seamus Coleman (hamstring), Jonjoe Kenny (ankle) and Richarlison (suspended) are unavailable.
Did you know?
Southampton have won five of their last seven Premier League home matches against Everton, but were beaten 2-1 in this fixture last season.
Danny Ings has scored in four of his five appearances for Southampton against Everton in all competitions, netting four times. He only has more goals for Saints against Spurs, with five.
Everton can achieve consecutive Premier League wins at Southampton for the first time.
Dominic Calvert-Lewin can become only the second player ever, after Sergio Aguero last season, to score in each of his side’s opening six Premier League matches.
Match officials
Referee: Kevin Friend. Assistants: Simon Beck, Eddie Smart. Fourth official: Steve Martin. VAR: Simon Hooper. Assistant VAR: James Mainwaring.
