Everton are looking to win their opening four matches of a top-flight season for the first time since 1969/70, when they went on to win the title.
Brighton & Hove Albion are targeting their first win at Everton in all competitions, at the ninth attempt.
Team news
Richarlison (ankle) faces a late fitness test, while Carlo Ancelotti will be without regular starters Allan (groin) and Andre Gomes.
Jonjoe Kenny (ankle) and Moise Kean (illness) are also ruled out.
Alireza Jahanbakhsh could be in contention for Brighton, but the match comes too soon for Davy Propper.
Yves Bissouma is available after completing a three-match ban following his red card at Newcastle United.
Did you know?
The last five Premier League meetings between these sides have been won by the home team, with Everton triumphing three times.
This will be Carlo Ancelotti’s 100th Premier League match in charge. Only five managers have won more of their first 100 in the competition than his 59.
Brighton are unbeaten in eight Premier League away matches, and have won three of the last four.
The Seagulls are averaging 14.7 shots per match in the league this season, their highest rate in any of their Premier League campaigns.
Match officials
Referee: Simon Hooper. Assistants: Derek Eaton, Scott Ledger. Fourth official: Jonathan Moss. VAR: Kevin Friend. Assistant VAR: Simon Beck.