Both sides are aiming to maintain their winning start to the season, but something has to give at Anfield.
Liverpool have won their last four Premier League home matches against Arsenal. However, the Gunners came out on top when the sides last met, at Emirates Stadium in July.
Liverpool's Jordan Henderson (muscle) will not be available with Thiago Alcantara, who played 45 minutes at Chelsea after replacing Henderson, in contention for his full debut.
Joe Gomez returned to training on Friday along with Billy Koumetio but Joel Matip (muscle) remains sidelined.
Only three top-flight fixtures have produced more defeats for reigning champions than the 16 between Arsenal and Liverpool.
Liverpool are unbeaten in their last 60 Premier League home matches, since April 2017.
Arsenal are looking to win their opening three matches of a Premier League season for the first time since 2004/05.
Mikel Arteta can become the first Arsenal manager to win his first match at Liverpool since Tom Whittaker in 1947.
Referee: Craig Pawson. Assistants: Lee Betts, Richard West. Fourth official: Anthony Taylor. VAR: Andre Marriner. Assistant VAR: Mark Scholes.