The Blues frontman sits in 48.1 per cent of squads, more than any other midfielder or forward.
Werner arrives at Stamford Bridge on the back of 28 goals and eight assists for RB Leipzig in last season's Bundesliga.
And he can make an immediate impact at Brighton & Hove Albion.
The Seagulls struggled defensively at home in their first season under Graham Potter, managing only four clean sheets.
Tottenham Hotspur's new right-back boasts a major goal threat for the visit of Everton. Doherty's 33 shots in the box and 15 shots on target were both league-leading totals among FPL defenders in 2019/20.
The Chelsea right-back offers points potential at both ends of the pitch at Brighton.
His record at Anfield makes him one of the standout captain options for Gameweek 1. At home last season, Salah's 15 goals were more than any other player in FPL.
The Arsenal attacker was far more prolific when facing teams lower down the table last term, netting 16 of his 22 goals against sides who finished in the bottom half.
Owned in just 3.3 per cent of squads, he offers a differential route into the Spurs attack. Alli entertains Everton on the back of one goal and two assists in pre-season.
The Chelsea striker's high ownership means he will be among the most-selected captains in Gameweek 1.
Southampton's forward stepped up his output towards the end of 2019/20, with all four of his goals last term coming in the final six Gameweeks.
Newcastle's new forward can make an immediate impact on his debut. Wilson has a prolific record against West Ham, scoring seven goals in his eight Premier League meetings with them.
Geoff Dance (@GeoffreyDance): After covering the four most-owned players in FPL, this Selection then finds some very nice low-ownership options. The two Spurs players look like particularly good picks.
Sam Bonfield (@FPLFamily): I'm loving that Adams pick. He outscored Danny Ings (£8.5m) in the last four Gameweeks and has had a great pre-season. Aubameyang looks like the perfect player for this week. His pre-season form has been excellent and he has a nice fixture first up. He's my Gameweek 1 captain.
Pranil Sheth (@Lateriser12): I'm really happy to see Alli in there. I'm betting on him in my own team, if he ends up playing the support striker role. The Bowen and Adams picks are great, too. They're the ones that also stand out for me in that price bracket.
Utkarsh Dalmia (@zophar666): There are a lot of differentials here with James, Alli, Bowen, Adams and Wilson all under five per cent ownership. Alli could be gold if he can rediscover his early form under Mourinho and Adams has the potential to match Ings at a significantly lower price.
Lee Bonfield (@FPLFamily): A good mix of solid picks and differentials. I'll also have Alli in my team. He's the type of player Jose Mourinho wants in this Spurs side, and if he can find the form he had at the end of last season he could be a superb mid-price midfielder pick.
Ben Crabtree (@FC_CrabDogg): I like the mid-priced and cheaper options but I'm not sure the Spurs duo are good picks now, given Everton's signings.
Neal Thurman (@nealjthurman): It's hard not to have any of the Arsenal defence against Fulham so I'd have Kieran Tierney (£5.5m) over Doherty. I don't trust Doherty to replicate his attacking prowess under Mourinho. As a bonus you get a little money to spend elsewhere.
Ben McNair (@drbenmcnair): With so much uncertainty at the start of a new season, it's a good call to go with Alexander-Arnold and Salah in the premium defender and midfield slots. Liverpool haven't made many changes this summer and we know what we can expect from those two.
Paul Gee (@FPLPaulGee): I love the Wilson pick. I've got a feeling that he and Ryan Fraser (£6.0m) can replicate their AFC Bournemouth form together at Newcastle. Aubamayang's form makes him a shoo-in and Alli playing in that No 10 role could be FPL gold.
Holly Shand (@FFCommunity_): Reassuringly, this is similar to my Gameweek 1 team. I like the inclusion of Werner as the third premium attacker: I have high hopes that both he and Chelsea will start the season strongly.
Nick (@WGTA_Nick): Both James and Bowen have a particularly low ownership but could easily be breakout stars this season.
Don't get caught out. GW1 deadline: 11:00 BST on 12 September. Register your team now at fantasy.premierleague.com.