There are just two points between these sides in the fight for the top four.
Manchester United are fifth will aim to build on Friday’s 1-1 draw at Tottenham Hotspur, while eight-placed Sheffield United seek to bounce back after their 3-0 defeat at Newcastle United.
Team news
Ole Gunnar Solskjaer has no new injury problems.
Sheffield United's on-loan goalkeeper Dean Henderson is unable to face his parent club, while defender John Egan is suspended and Jack O'Connell is recovering from a knee injury.
Chris Wilder hopes Phil Jagielka will be able to shake off an ankle problem and step into the defence.
Did you know?
Since Bruno Fernandes’ debut, no Man Utd player has scored more goals (four), made more assists (four), had more shots (38) and shots on target (15), created more chances (26) or played more passes into the box (98, including crosses) than he has.
Man Utd are unbeaten in 12 matches in all competitions (W8 D4), netting 30 goals in that spell while conceding just three. They last had a longer run without defeat between November 2016 and January 2017, with 17 matches.
Sheffield United can become the first Yorkshire team to win a top-flight match at Old Trafford in 43 attempts, with Sheffield Wednesday being the last side to triumph there in 1986.
The Blades have given Premier League debuts to players from each nation in Great Britain this season, with Welshman Kieron Freeman making his bow against Newcastle United last time out.
Match officials
Referee: Anthony Taylor. Assistants: Gary Beswick, Adam Nunn. Fourth official: Jarred Gillett. Replacement official: Robert Merchant. VAR: Stuart Attwell. Assistant VAR: Simon Beck.
