Despite Wolves enjoying plenty of possession in their first match back after the COVID-19 outbreak, the best chance of the first half fell to West Ham's Pablo Fornals, who blazed his volley high and wide.
The introduction of Adama Traore and Neto proved to be the turning point, with Traore crossing for Jimenez to head in on 73 minutes for his 14th goal of the season.
Neto scored the second with a thunderous volley past Lukasz Fabianski in the 84th minute to make it seven matches unbeaten for Nuno Espirito Santo's side.
They move up to sixth place with 46 points, level with fifth-placed Man Utd, and two adrift of Chelsea in fourth.
West Ham sit 17th on 27 points, ahead of 18th-placed AFC Bournemouth on goal difference.
West Ham: 23 Jun v Spurs (A)
Wolves: 24 Jun v AFC Bournemouth (H)