And Sterling’s prospects for goals and assists can be decisive.
The winger is the only Man City player to rank among the Premier League's top three for both shots in the box and key passes, producing 61 and 38 respectively.
Remember the FPL deadline is at 17:00 BST on Wednesday, 17 March.
Arsenal's No 1 offers multiple routes to points against Man City and Brighton & Hove Albion. Leno has three clean sheets in his last four matches, while his total of 104 saves ranks second among goalkeepers this season.
The centre-back provides excellent value for the Blades' pair of Gameweek 30+ fixtures. Egan also boasts a strong goal threat, with his total of 17 shots in the box ranking among the top 10 defenders in 2019/20.
The Argentinian has been a standout FPL performer in Newcastle’s home matches this season. Fernandez has averaged 5.6 points per start at St James’ Park.
At home, his 43 shots and 58 chances created are team-leading totals for Man City. De Bruyne has also been their most explosive performer at Etihad Stadium this season, producing five double-digit returns.
An ownership of just 16.8 per cent suggests he could be a major captaincy differential for managers looking to make up ground in FPL mini-leagues.
The playmaker’s contribution will be vital for Aston Villa's pair of home encounters with Sheffield United and Chelsea. Grealish has been involved in 47 per cent of his side’s goals at Villa Park this term, supplying five assists and finding the net on three occasions.
A visit from Leicester City hands the Watford winger the chance to extend his outstanding home form. Sarr has produced 47 points in his five matches under Nigel Pearson at Vicarage Road, including double-digit hauls against Manchester United and Liverpool.
The Argentinian has a fine record at Etihad Stadium against both of his Double Gameweek opponents. Aguero scored a hat-trick in the corresponding fixture with Arsenal last season and has six goals in five home appearances against Burnley in all competitions.
The Arsenal forward has averaged 5.9 points per match under Mikel Arteta. Away from home, Aubameyang’s total of nine goals is joint-top among all players in FPL ahead of his visits to Man City and Brighton.
Holly Shand (@FFCommunity_): There's a lot of similarity between this and my Free Hit team. I'm also backing the Sheffield United defence, but I think John Lundstram (£4.9m) has the biggest potential. I have the same Man City trio of De Bruyne, Sterling and Aguero, so fingers crossed for some returns!
Tom (@WGTA_FPL): A very strong team for the Double Gameweek in line with my own side. Aside from the Double Gameweek picks, I like the Pukki differential. A Friday night meeting with Southampton could see the Finnish talisman return with a bang.
Ash (@FPLHints): With Guardiola hinting at rotation in his pre-match press conference I think it's a risk having Sterling and Aguero. Grealish, Pukki and Sarr make sense as they have it all to play for.
Paul Gee (@FPLPaulGee): Aside from the obvious Double Gameweek picks, I love the Sarr selection. He was bang on form before the break, and now is the time to invest in teams that are going to be trying to preserve their Premier League status.
Sam Bonfield (@FPLFamily): I find the lack of Liverpool players fascinating. For me, Trent Alexander-Arnold (£7.8m) is still a must, even if the likes of De Bruyne, Sterling, Aguero and Aubameyang do take up a huge chunk of the budget. Double Sheffield United in defence looks a great idea and I really like the Pukki pick given Norwich's motivation.
Ben Crabtree (@FC_CrabDogg): I like the midfield. I'm personally just missing Sterling from that and it's worrying.
Ben McNair (@drbenmcnair): Sterling may seem pricey given his modest returns this season but his pedigree, along with Pep Guardiola's comments about his natural fitness, make him a great selection this week.