If Liverpool beat the Hammers, they will match Manchester City's top-flight record of 18 consecutive victories, set between August and December 2017.
Not only that, a victory would also be the Reds' 21st in a row at Anfield. That would tie the mark for the most consecutive home wins in the top flight, a feat that belongs to Liverpool's 1972 side managed by Bill Shankly.
But could there be a bad omen for Jurgen Klopp's team?
This will be the leaders' first Premier League match on a Monday since facing West Ham in February last year.
They drew 1-1 that night, and it was the last time Liverpool failed to win a match in which they had scored the opening goal.
So, will a shock be on the cards at Anfield? Or can Liverpool equal two records in one match?