The news comes as a huge disappointment to the 68,000+ managers who have already bought him ahead of Spurs' Gameweek 27 trip to Chelsea.
His two goals and 13 points against Villa had earned the 27-year-old his fourth double-figure haul in 11 Gameweek appearances under Jose Mourinho.
Son's 11 per cent ownership must now look for replacements, and they could start by considering other Spurs players as the north Londoners reconfigure their attack.
The injury could lift the prospects of attacking returns from Dele Alli (£8.4m).
With Harry Kane (£10.8m) also sidelined, Alli could now be handed the lone striker role for Spurs.
Alli has scored five goals and supplied four assists since Mourinho took charge in Gameweek 13, compared with Son's six goals and four assists.
He has averaged 5.4 points per match under the Portuguese.
|Shots in box||27||23|
|Shots on target||17||13|
Owned by only 5.4 per cent, Alli is now shaping up to be a strong differential for managers looking to navigate the Gameweek 28 schedule, when Arsenal, Aston Villa, Manchester City and Sheffield United are set to blank.
But a number of players with favourable schedules at other clubs should also be considered.
According to the Fixture Difficulty Ratings (FDR), the Reds' next three matches score only two.
They have averaged 5.2 and 5.1 points per match respectively this season.