Arsenal can leapfrog Everton with a second successive home win, while Carlo Ancelotti's Toffees are unbeaten since New Year's Day and have won their last two matches.
Hector Bellerin (groin) and Sokratis Papastathopoulos (knee) will be assessed by Arsenal. Mesut Ozil and Lucas Torreira are available.
Everton's Andre Gomes (ankle) is fit for selection, while Bernard (knock) is also available. Theo Walcott (knee) will be assessed ahead of facing his former side.
Arsenal are unbeaten in their last 23 Premier League home matches against Everton, since January 1996, and have won 19 of those.
Pierre-Emerick Aubameyang has scored 30 goals in 37 Sunday Premier League matches, compared with 17 goals in 36 on other days of the week.
Dominic Calvert-Lewin has scored 11 Premier League goals this season. The last English player to score more in a campaign for Everton was Kevin Campbell with 12 in 1999/00.
Ancelotti can become only the third manager to beat Arsenal three times at Emirates Stadium, after Sir Alex Ferguson and Pep Guardiola. The Italian has previously won there with Chelsea and Bayern Munich.
Referee: Stuart Attwell. Assistants: Adam Nunn, Simon Long. Fourth official: Simon Hooper. VAR: Craig Pawson. Assistant VAR: Stephen Child.