Both sides are aiming to avoid a third successive defeat as they meet on the south coast.
Team news
Southampton winger Nathan Redmond has been ruled out for at least a month through injury.
Sofiane Boufal (foot) is a major doubt while Kyle Walker-Peters has picked up a minor calf problem and misses out.
Aston Villa defender Tyrone Mings (illness) is available for selection this weekend while Keinan Davis (hamstring) is expected to return to training next week.
John McGinn is making progress in his recovery from a fractured ankle and has begun running in the gym.
Did you know?
Southampton striker Shane Long has been directly involved in 10 goals in his last seven Premier League starts against Aston Villa, scoring six and assisting four.
Saints can win a third successive Premier League match against Villa for the first time since November 2000.
Jack Grealish has created 68 chances in the Premier League this season, the most by an English player.
Excluding own goals, Villa’s last two Premier League goals have been headers. None of their previous 31 this term were headed.
Match officials
Referee: Craig Pawson. Assistants: Richard West, Nick Hopton. Fourth official: Keith Stroud. VAR: Simon Hooper. Assistant VAR: Andy Halliday.