The Senegal international is set to miss the second match of the Reds' Double Gameweek 24 against West Ham United on Wednesday evening.
He has not recovered from the muscle problem that forced him off against Wolverhampton Wanderers.
The winger's expected absence has already persuaded 135,000 managers to swap him out for Salah.
And Liverpool's very favourable schedule strengthens the Egyptian's appeal as a like-for-like replacement.
Their next five matches score just two in the Fixture Difficulty Ratings (FDR).
|25||SOU (H)||2||28||WAT (A)||2|
|26||NOR (A)||2||29||BOU (H)||2|
However, Klopp is optimistic that Mane will be back in contention to face Norwich City in Gameweek 26.
Managers with strong benches may be tempted to hold on to the 27-year-old, whose average of 6.7 points per match (ppm) is almost identical to the 6.8ppm of Salah.
Kevin De Bruyne (£10.6m), the top-scoring midfielder in FPL, has also been a popular replacement.
De Bruyne produced two assists and 11 points against Spurs in a 2-2 draw in Gameweek 2.
Mane's potential absence could also allow managers to freshen up their attacks and take advantage of other sides' favourable schedules.
For example, Sheffield United's next five matches also score just two in the FDR.
Aguero has six goals and 37 points in his last three Gameweeks for Man City.
He also has a strong upcoming schedule, with five of the Gunners' next eight matches scoring two in the FDR.
|25||BUR (A)||3||29||WHU (H)||2|
|26||NEW (H)||2||30||BHA (A)||3|
|27||EVE (H)||2||30||SOU (A)||2|
|28||MCI (A)||5||31||NOR (H)||2|