Newcastle United, who lie 13th, are aiming to end a run of four matches without a win.
Fourth-placed Chelsea are seeking to maintain their strong away form after winning seven of their 11 matches on the road.
Javier Manquillo, Dwight Gayle (both thigh), DeAndre Yedlin, Jack Colback (both knee), Ki Sung-Yueng (knock), Paul Dummett (hamstring) and Yoshinori Muto (hip) are sidelined for Newcastle.
Andy Carroll will be assessed, while JonJo Shelvey, Allan Saint-Maximin and Fabian Schar are all closing in on a return.
Chelsea head coach Frank Lampard confirms Christian Pulisic will be sidelined for two weeks. N'Golo Kante (hamstring) will be assessed while Ruben Loftus-Cheek (Achilles) continues to progress.
Newcastle's head coach Steve Bruce has won just one of his 22 Premier League matches against Chelsea (D5 L16).
Miguel Almiron has scored with his last two shots on target in the Premier League, having failed to find the net with any of his first 15 such efforts in the competition.
Chelsea are looking to record consecutive Premier League away wins against Newcastle for the first time since winning 2-0 in both 2007/08 and 2008/09.
With 25 victories over Newcastle in the Premier League, Chelsea have only beaten Spurs more often in the competition, doing so 29 times.
Referee: Chris Kavanagh. Assistants: Daniel Cook, Constantine Hatzidakis. Fourth official: Anthony Taylor. VAR: Kevin Friend. Assistant VAR: Andy Halliday.