De Bruyne has been a reliable source of points when playing at the Etihad Stadium.
He has averaged 8.1 points per home match, producing double-figure hauls in three of his seven appearances.
The Belgian is given the vice-captaincy in a Scout Selection who line up in a 3-4-3 formation, with Son Heung-min (£10.1m) handed the armband.
FPL's top-scoring defender is a strong all-round option away to Brighton & Hove Albion. Lundstram has three goals, three assists and six clean sheets over his 17 Gameweek appearances.
Owned by only 3.8 per cent, the wing-back could be a big differential against Crystal Palace. The Dutchman's average of 4.3 points per match is second among Newcastle players this season.
The South Korean has a goal or an assist in six of the last eight Gameweeks ahead of Tottenham Hotspur's home encounter against Chelsea. That includes three double-figure hauls in his five matches under Jose Mourinho.
The Spurs midfielder has been a big success against Chelsea, scoring five goals and supplying an assist in his last four Premier League meetings. Alli has 40 points since Mourinho's arrival, more than any team-mate.
An advanced role as a No 10 against Arsenal helped the Belgian to the top of the FPL midfield standings on 116 points. De Bruyne's total of five double-figure returns in 2019/20 is more than any other Man City player.
The winger has scored three goals in his last two matches in all competitions for Man City. Owned by 24.8 per cent compared with the 42.3 per cent of De Bruyne, Sterling could be a big armband alternative in Gameweek 18.
Everton's frontman scored twice and earned 13 points in their previous home match against Chelsea. Calvert-Lewin entertains an Arsenal side who have conceded at least two goals in seven of their last eight in all competitions.
Lee Bonfield (@FPLFamily): The double-up on the Spurs midfield feels too much. I know Chelsea's defence hasn't been great but they're still a good side, fighting for the top four. Frank Lampard will want a reaction after a run of bad form, too.
Holly Shand (@FFCommunity_): I expect Alli and Son to do well against Chelsea - I wish I had both in my squad! Rashford and Jimenez look like good shouts for goals on the road.
Ben Crabtree (@FC_CrabDogg): Guaita has been doing great for me so happy to see him in there. I own a lot of these players, so I hope this team does well.
Ben McNair (@drbenmcnair): I like the Calvert-Lewin pick. At his price he looks good value at home to a vulnerable Arsenal defence. A couple of other budget enablers I think will do well are Jack Grealish (£6.2m) and Danny Ings (£6.4m), who face off at Villa Park. Neither side are strong defensively and both of those players have been significant goal threats in recent weeks.