Manchester City, who returned to form with a 4-1 win at Burnley on Tuesday, are looking for a fourth successive home win.
Manchester United claimed an impressive 2-1 victory against Tottenham Hotspur in midweek but are seeking just their second away win.
Team news
Man City welcome back Oleksandr Zinchenko from a knee injury but Pep Guardiola is unsure whether the left-back is fit enough to start.
Sergio Aguero is still injured and remains unavailable, as do Aymeric Laporte and Leroy Sane.
Anthony Martial is expected to be fit enough to make the Man Utd squad having missed the win over Spurs.
Ole Gunnar Solskjaer thinks Paul Pogba will return before the end of the year but is likely to miss this match along with Eric Bailly, Tim Fosu-Mensah and Diogo Dalot.
Did you know?
Man City have won 15 Premier League matches against Man Utd, with 10 of those coming in the last eight years. Only Chelsea have won more against them, with 18.
Having triumphed 3-1 and 2-0 in last season’s Premier League meetings, Man City can become the first team to beat Man Utd by at least two goals in three consecutive top-flight meetings since Liverpool did so four times in a row between 1978 and 1979.
Man Utd have only lost one of their last four away league matches against Man City (W2 D1), although that defeat came in this fixture last season.
United are unbeaten in their last five Premier League matches against last season’s top six sides (W2 D3), including all four matches this term. They last went six consecutive such matches without defeat back in March 2016 under Louis van Gaal.
Match officials
Referee: Anthony Taylor. Assistants: Gary Beswick, Adam Nunn. Fourth official: Mike Dean. VAR: Michael Oliver. Assistant VAR: Marc Perry.
